Welcome to NRDTD

The non-coding RNAs (ncRNAs) are RNA molecules that are not translated into proteins. The ncRNAs include highly abundant and functionally important RNAs such as microRNAs, long ncRNAs, intronic RNAs and repetitive RNAs. These ncRNAs may affect normal gene expression and disease progression, making them a new class of targets for drug discovery. NRDTD (the ncRNA Drug Targets Database) is a database that curated clinically or experimentally supported evidence for ncRNAs as drug targets. Each entry in NRDTD has five items for annotation; they are ncRNA name, drug name, disease name, the reference PubMed ID, and the evidence supporting the ncRNAs as drug targets from the original paper. In addition, the NRDTD also provides related links of ncRNA, drug and disease.

Currently, users can

  • -browse the clinically or experimentally supported ncRNAs as drug targets association data;
  • -search the clinically or experimentally supported ncRNAs as drug targets association data;
  • -download the related data in the NRDTD database;
  • -submit new entries to the NRDTD database.

In the future, the ncRNA Drug Targets Database will

  • -be updated timely;
  • -develop tool for predicting novel associations of ncRNAs as drug targets.

Statistics:

Currently, NRDTD collected 165 entries that include 97 ncRNA genes, 94 drugs from more than 3000 papers.

History:

June, 2017, the NRDTD database was updated with improvements.

April, 2017, the NRDTD database was updated with 6 ncRNA-drug entries and improvenments.

March, 2017, the NRDTD database was updated with improvements.

January, 2017, the NRDTD database was updated with improvements.

October, 2016, the original NRDTD database was released.

Contact us:

Xing Chen

Professor

Director of Institute of Bioinformatics, China University of Mining and Technology

School of Information and Control Engineering, China University of Mining and Technology

Address: No.1,Daxue Road, Xuzhou, Jiangsu, 221116, P.R.China

Email:xingchen@cumt.edu.cn

Homepage (English): http://www.researchgate.net/profile/Xing_Chen40/publications

Homepage (Chinese): http://www.escience.cn/people/xingchen

Chen Group (Chinese): http://www.escience.cn/people/chengroup/index.html

How to cite us:

NRDTD: a database for clinically or experimentally supported non-coding RNAs and drug targets associations. Xing Chen*, Ya-Zhou Sun, De-Hong Zhang, Jian-Qiang Li*, Gui-Ying Yan, Ji-Yong An, Zhu-Hong You. Database. 2017, 2017:bax057 (SCI, IF: 3.290)

You can search the entries by such keywords:

Welcome to submit new entries to the database.

NRDTD Tutorial

May 8, 2017

Non-coding RNAs (ncRNAs) are RNA molecules that are not translated into proteins. Emerging evidence has shown that ncRNAs play critical roles in various important biological processes. They can affect the expression of other genes through a variety of mechanisms. Therefore, the capacity of ncRNAs to affect gene expression makes them potential targets for drug development. Targeting ncRNA has the potential to offer novel therapeutic opportunities. Non-coding RNAs are representing one class of important biological molecules in understanding the mechanisms of drug development, and in identifying new drug targets for disease treatment.

NRDTD (the ncRNA Drug Targets Database) is a resource that curated clinically or experimentally supported non-coding RNAs and drug targets association data. Currently, users can browse and search the database by the names of ncRNAs and drugs. Moreover, users can get descriptions for the associations of non-coding RNAs and drug targets for each entry in more details, such as the drug, sequence and disease information from KEGG, Genbank and OMIM database respectively. In addition, the non-coding RNAs were classified as different species to facilitate different research interests of users.

The detailed usage of the database is as followings:

[1] Visiting NRDTD: Log on NRDTD at http://chengroup.cumt.edu.cn/NRDTD/.

[2] To browse non-coding RNAs and drug targets association data in the database, please click the menu "Browse" (Figure 1). For example, for the non-coding RNAs and drug targets association from the candidate ncRNAs, select “ncRNA” (step 1). To browse the entries related to lncRNA, please click “lncRNA” (step 2) and select the one you are interested in (step 3). The result will be shown in the right panel (step 4). To browse the entries related to the candidate drug, please click “drug” and select the one you are interested in. If you want to read more information about the pathways and functions annotation or description, you can double click corresponding content to get complete information (step 5).

Figure 1. A demo for browsing data in the database

[3] To search data in the database, select the menu "Search". NRDTD provides functions of "search" by full or partial names of ncRNAs, drugs or diseases and PMID of reference. Input your candidate keywords into corresponding blanks and submit the query.

[4] To submit new entries to the database, select the menu "Submit". The users need to input their data into corresponding blanks and then submit the query. We will further curate the submitted information to determine whether to add the new entries to the database or not.

[5] Currently, all data in NRDTD is free only for academic users and please contact Dr. Xing Chen for commercial using. If you used the data in NRDTD, please cite “….”

If there are any comments or suggestions, please contact Dr. Xing Chen at xingchen@amss.ac.cn or xingchen@cumt.edu.cn

The whole dataset of disease-related ncRNAs and drugs association data ( txt or excel).

The list of ncRNAs ( txt or excel).

The list of drugs ( txt or excel).

The list of diseases ( txt or excel).